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Is it possible to disable power to the USB ports when the miniPC is turned off?
Unfortunately with Linux sometimes the BT freezes and the only way to make it work again is to turn off, unplug the power and restart.
If I just reboot the problem doesn't go away.
Maybe there is some setting in the Bios but I haven't found it.

That's typically a setting you'll find in the BIOS of the system. It depends on the features available for your model, so I don't know if it's available or not, but suspect it should be.